Chris Halbrook, PhD
Targeting metabolic mechanisms of chemoresistance using patient-derived organoids
The Halbrook lab focuses on identifying and targeting interactions among the cell populations found in pancreatic tumors. Those techniques have led to seminal findings describing mechanisms of metabolic crosstalk with functional consequences for tumor growth, chemoresistance and immune suppression. With Sky Foundation’s support, the lab is using patient-derived organoid models to identify and target the metabolic mechanisms of chemoresistance in pancreatic cancer.
Through this work the lab expects to make significant inroads toward improving patient response to standard-of-care therapies.
Christopher Halbrook, PhD is an Assistant Professor at the University of California Irvine in the Department of Molecular Biology and Biochemistry, with memberships in the Chao Family Comprehensive Cancer Center, the UCI Cancer Research Institute and the UCI Institute for Immunology. His dedication to pancreatic cancer research began during graduate training with Dr. Howard Crawford at Stony Brook University and the Mayo Clinic, and was strengthened during his postdoctoral fellowship at the University of Michigan with Drs. Costas Lyssiotis and Marina Pasca di Magliano.
Seed grants start at $50,000 — awarded by scientists, reported on annually.
Donate →Chris Halbrook, PhD
Targeting metabolic mechanisms of chemoresistance using patient-derived organoids
The Halbrook lab focuses on identifying and targeting interactions among the cell populations found in pancreatic tumors. Those techniques have led to seminal findings describing mechanisms of metabolic crosstalk with functional consequences for tumor growth, chemoresistance and immune suppression. With Sky Foundation’s support, the lab is using patient-derived organoid models to identify and target the metabolic mechanisms of chemoresistance in pancreatic cancer.
Through this work the lab expects to make significant inroads toward improving patient response to standard-of-care therapies.
Christopher Halbrook, PhD is an Assistant Professor at the University of California Irvine in the Department of Molecular Biology and Biochemistry, with memberships in the Chao Family Comprehensive Cancer Center, the UCI Cancer Research Institute and the UCI Institute for Immunology. His dedication to pancreatic cancer research began during graduate training with Dr. Howard Crawford at Stony Brook University and the Mayo Clinic, and was strengthened during his postdoctoral fellowship at the University of Michigan with Drs. Costas Lyssiotis and Marina Pasca di Magliano.
Seed grants start at $50,000 — awarded by scientists, reported on annually.
Donate →