Pancreatic cancer
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Next steps after diagnosis

A diagnosis raises urgent questions: what should I do first, where do I go for care, what information do I need? These steps are widely recommended by leading cancer centers and medical guidelines.

Next steps after diagnosis
1

Confirm the diagnosis and stage

Accurate diagnosis is essential before making treatment decisions. Tests may include:

Imaging scans. CT, MRI or PET to identify tumor location and spread.
Endoscopic ultrasound (EUS). Allows close imaging and tissue biopsy.
Biopsy. Confirms cancer type under a microscope.
Blood tests. Including CA 19-9, a tumor marker sometimes elevated in pancreatic cancer.

These results help determine whether the cancer is localized, borderline resectable, locally advanced or metastatic.

Source
American Cancer Society — How pancreatic cancer is diagnosed
2

Seek a second opinion

Pancreatic cancer is complex, and outcomes improve when treatment decisions are made by multidisciplinary teams at high-volume centers. Even if you feel confident in your current provider, a second opinion can confirm staging, expand your treatment options, and ensure surgical expertise is available.

Sky Foundation partners with Henry Ford Health and nationally recognized pancreatic surgeons to provide these expert evaluations. Contact us for a connection to the team of doctors we suggest.

3

Undergo genetic and biomarker testing

Both germline (inherited) and somatic (tumor-specific) genetic testing are now standard of care for all pancreatic cancer patients. These tests can:

Identify inherited syndromes that may affect family members.
Reveal mutations — such as BRCA1/2, PALB2, MSI-H, KRAS or NTRK — that guide targeted therapies or trial eligibility.
Inform risk for other cancers.
Source
National Cancer Institute — Pancreatic cancer genetics
4

Understand treatment pathways

Treatment depends on the stage and overall health of the patient. Standard approaches include:

Surgery. The only potentially curative option, performed if the tumor can be safely removed. The Whipple procedure (pancreaticoduodenectomy) is the most common.
Chemotherapy. Drugs such as FOLFIRINOX or gemcitabine-based regimens, given before (neoadjuvant) or after (adjuvant) surgery, or as primary treatment for advanced disease.
Radiation therapy. May be used in selected cases to shrink tumors or relieve symptoms.
Palliative care. Managing symptoms, nutrition and quality of life from the start of treatment.
Source
NCCN Guidelines for Patients — Pancreatic cancer
5

Explore clinical trials early

Clinical trials test new drugs, combinations and therapies. Enrolling early provides access to promising treatments that may improve outcomes beyond standard care.

Sky Foundation can help identify trials in Michigan and nationally. Karmanos Cancer Institute has been an NCI-Designated Comprehensive Cancer Center since 1978 — one of only 57 in the United States, and the only cancer hospital in Michigan with that designation. It offers treatment and trials not available at other hospitals, and welcomes patients coming in for a second opinion.

Source
Clinical trials at Karmanos Cancer Institute
Source
ClinicalTrials.gov — Pancreatic cancer studies
6

Build your care team

A strong care team typically includes:

Surgical oncologist. For surgical options.
Medical oncologist. For chemotherapy and systemic therapy.
Radiation oncologist. For targeted radiation when indicated.
Gastroenterologist. For digestive issues and stent placement.
Genetic counselor. For inherited cancer risk assessment.
Nutritionist and palliative care specialists. For symptom and diet management.

Multidisciplinary coordination improves survival and quality of life.

Source
Mayo Clinic — Pancreatic cancer treatment team
7

Prepare for appointments

Bring a trusted family member or caregiver to appointments and keep written questions. Helpful questions include:

What type and stage of pancreatic cancer do I have?
Is my cancer potentially operable?
What genetic or biomarker tests are recommended?
What are the treatment options in my situation?
Am I eligible for any clinical trials?
What side effects should I expect?
Source
Sky Foundation — Questions for yourself and your medical team
8

Consider supportive resources

Newly diagnosed patients and caregivers benefit from:

Patient navigation programs. For clinical trial matching and insurance questions.
Survivor and caregiver support groups. To reduce isolation.
Financial and legal counseling. For managing treatment costs.
Source
CancerCare — Pancreatic cancer support

Key takeaway

Your first steps should include confirming the diagnosis, seeking expert opinions and undergoing genetic testing. Building a multidisciplinary care team and considering clinical trials early can expand treatment options and improve outcomes.

Next article
Treatment options
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